At the glass transition temperature (Tg), a material transitions from Cp (glassy state) to Cp (rubbery state) causing an inflection in the curve over a temperature range. 4, pure DOTAP monolayer had no obvious phase transition points at the three pHs. In vivo studies on liposomal delivery with the TSL system to a tumor site in nude mice with implanted human BLM melanoma in temperature-controlled dorsal skin-fold window chambers were performed. 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 0102030405060 mg EtOH / ml H2O m i s c i b i l i t y tr a n s i ti o n te m p (C) Onset of transition C ompleti n of trantiti PE’s don’t make good vesicles. The invention relates to enantiomerically pure DOTAP chloride and stable crystal modifications of (2R,S)-, (25)- and (2R)-DOTAP chloride, to a process for the preparation of these modifications, and t The observed transition temperature is known to be dependent upon the rate at which the temperature is changed, which accounts for the many different values in the literature. Studies of membrane phase domain behavior using the probe Laurdan (6-dodecanoyl-2-dimethy-laminonaphthalene) indicated that both paclitaxel and DOTAP were miscible with the phosphatidylcholine phase. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Miscibility transition temp vs EtOH conc. The designed liposomes were … DOTAP exerted a major ﬂuidizing effect on DMPC, DPPC, and DSPC membranes, and the addition of paclitaxel at 3–8 mol% did not increase ﬂuidity further. X-ray diffraction was used to study the phase transition of fully-hydrated DOPE to determine the rate-independent transition temperature, T(LH). Below the transition temperature, the system is essentially stable and the release of the encapsulated material is negligible, both in buffer and in 50% serum. As shown in Fig.
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